Hawthorne G, Robson S, Ryall E A, Sen D, Roberts S H, Ward Platt M P
BMJ. 1997 Aug 2;315(7103):279-81. doi: 10.1136/bmj.315.7103.279.
To determine whether the St Vincent declaration (1989) target of diabetic pregnancy outcome approximating non-diabetic pregnancy outcome in near to being achieved.
Prospective collection of population based information on pregnancies in women with diabetes from all participating hospitals.
District general and teaching hospitals of the former Northern region.
111 diabetic women booking with pregnancy during 1 January to 31 December 1994.
Diabetic control, perinatal mortality rate, fetal abnormality rate.
The perinatal mortality rate was 48/1000 for diabetic pregnancies compared with 8.9/1000 for the background population (odds ratio 5.38; 95% confidence interval 2.27 to 12.70) and the neonatal mortality rate was 59/1000 compared with 3.9/1000 (15.0; 6.77 to 33.10). Two late neonatal deaths were due to congenital heart defects. Six per cent of all fetal losses (6/109 cases) were due to major malformations. The congenital malformation rate was 83/1000 compared with 21.3/1000 (3.76; 2.00 to 7.06) in the background population.
Diabetic pregnancy remains a high risk state with perinatal mortality and fetal malformation rates much higher than in the background population.
确定《圣文森特宣言》（1989 年）中关于糖尿病妊娠结局接近非糖尿病妊娠结局的目标是否接近实现。
前瞻性收集所有参与医院中糖尿病女性妊娠的人群信息。
原北部地区的区综合医院和教学医院。
1994 年 1 月 1 日至 12 月 31 日期间登记妊娠的 111 名糖尿病女性。
糖尿病控制情况、围产儿死亡率、胎儿畸形率。
糖尿病妊娠的围产儿死亡率为 48/1000，而背景人群为 8.9/1000（比值比 5.38；95%置信区间 2.27 至 12.70），新生儿死亡率为 59/1000，而背景人群为 3.9/1000（15.0；6.77 至 33.10）。两例晚期新生儿死亡归因于先天性心脏缺陷。所有胎儿丢失中 6%（6/109 例）归因于严重畸形。先天性畸形率为 83/1000，而背景人群为 21.3/1000（3.76；2.00 至 7.06）。
糖尿病妊娠仍然是一种高风险状态，围产儿死亡率和胎儿畸形率远高于背景人群。
