Gu L, Zhang L, Gu F
Third Hospital, Beijing Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1996 Oct;31(10):582-5.
To study the differences of histologic dating and steroid receptors between ectopic and eutopic endometrium in patients with endometriosis.
Histologic examinations were done on eutopic and ectopic endometrium in 28 patients with pelvic endometriosis, and estrogen and progestrone receptors concentrations were determined by immunochemical ABC method in 15 patients. All the ectopic tissues were biopsied from peritoneal lesions.
In 67.9% patients, the ectopic endometrium development was retardated and 14.3% accelerated as compared with eutopic endometrium, and only 17.9% identical. The estrogen receptors (ER) and progesterone receptors (PR) contents of ectopic endometrium were significantly lower than those of eutopic endometrium in glandular cells (P < 0.01, P < 0.05 respectively), while differences were not significant in stroma cells.
The advantage of the immunochemical technique is that it can definitely locate the site of receptors in the histologic section. The difference in histologic dating and ER and PR concentrations in the eutopic and ectopic endometrium may be accounted for by the different steroid environments and pathogenic theory of peritoneum metaplasia.
研究子宫内膜异位症患者异位内膜与在位内膜在组织学分期及甾体激素受体方面的差异。
对28例盆腔子宫内膜异位症患者的在位内膜和异位内膜进行组织学检查，并用免疫化学ABC法测定其中15例患者的雌激素和孕激素受体浓度。所有异位组织均取自腹膜病变活检标本。
与在位内膜相比，67.9%患者的异位内膜发育滞后，14.3%患者的异位内膜发育加速，仅17.9%患者的异位内膜与在位内膜发育同步。异位内膜腺上皮细胞的雌激素受体（ER）和孕激素受体（PR）含量显著低于在位内膜（分别为P<0.01，P<0.05），而间质细胞中差异无显著性。
免疫化学技术的优点是能在组织切片上准确定位受体部位。在位内膜与异位内膜在组织学分期及ER、PR含量上的差异，可能与甾体激素环境及腹膜化生的发病机制不同有关。
