Nisolle M, Casanas-Roux F, Wyns C, de Menten Y, Mathieu P E, Donnez J
Catholic University of Louvain, Department of Gynecology, St. Luc Hospital, Brussels, Belgium.
Fertil Steril. 1994 Oct;62(4):751-9. doi: 10.1016/s0015-0282(16)57000-9.
To evaluate estrogen receptors (ER) and progesterone receptors (PR) content in glandular and stromal cells of eutopic and ectopic endometrium.
A recently advanced stereographic computer technology was applied for the investigation of steroid receptors.
University hospital department of gynecology.
Biopsies of endometrium and typical peritoneal endometriotic lesions were taken from 19 infertile patients with laparoscopically proved endometriosis. Endometrial biopsies were also taken from 15 patients without endometriosis. All of them were untreated.
In normal endometrium, the highest concentrations of ER and PR occurred in the epithelial and stromal cells during the late proliferative phase of the menstrual cycle. Estrogen receptor and PR content declined throughout the secretory phase. Progesterone receptor content was found not to be significantly decreased in the stroma during the early secretory phase and quite high in the late secretory phase. In peritoneal endometriotic lesions, the highest concentrations of ER and PR were found during the late proliferative phase. When compared with normal endometrium, a lower ER content ans a similar PR content were observed, and the cyclic changes in peritoneal endometriosis lesions were also similar.
A new computerized technology for the evaluation of ER and PR in eutopic and ectopic endometrium. Although the ER content was found to be lower in endometriotic tissue when compared with endometrium, the cyclic pattern was similar in both eutopic and ectopic endometrium. Progesterone receptor content was similar in both tissues, except during the late secretory phase in ectopic glandular epithelium in which a high persistent PR content was observed.
评估在位内膜和异位内膜的腺细胞及基质细胞中雌激素受体（ER）和孕激素受体（PR）的含量。
应用一种最新发展的立体计算机技术来研究甾体激素受体。
大学医院妇产科。
对19例经腹腔镜证实患有子宫内膜异位症的不孕患者取子宫内膜活检及典型的腹膜子宫内膜异位病灶活检。另取15例无子宫内膜异位症患者的子宫内膜活检。所有患者均未接受治疗。
在正常子宫内膜中，月经周期增殖晚期上皮细胞和基质细胞中ER和PR浓度最高。整个分泌期雌激素受体和PR含量下降。在分泌早期基质中PR含量未见明显下降，在分泌晚期相当高。在腹膜子宫内膜异位病灶中，增殖晚期ER和PR浓度最高。与正常子宫内膜相比，ER含量较低，PR含量相似，腹膜子宫内膜异位病灶的周期性变化也相似。
一种用于评估在位和异位子宫内膜中ER和PR的新计算机技术。虽然发现子宫内膜异位症组织中的ER含量低于子宫内膜，但在位和异位子宫内膜的周期性模式相似。两种组织中的PR含量相似，除了在异位腺上皮的分泌晚期观察到持续的高PR含量。
