Wu C, Xia W, Wu X, Li R, Huang X, Yan Y, Huang D
Institute of Family Planning, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1996;16(2):117-20. doi: 10.1007/BF02887971.
Effect of domestically-made levonorgestrel-releasing intrauterine device (LNG, release rate, 6 micrograms/day) on the endocrine system and menstruation in monkeys was investigated. The results showed that the Estradiol (E2) and progesterone (P) levels were significantly decreased 2 ovulatory cycles after insertion of the devices as compared with those before insertion in 3 monkeys (P > 0.001), suggesting an evident ovulation-suppressing effect. In 1 monkey, the E2 and P levels were the same before and after insertion, and expulsion of device was found in the monkey later. The plasma LNG concentration in 3 animals was 493.69-454.60 pg/ml and plasma LNG was not detected in 1 monkey. The hormone level returned to normal level after removal of the devices.
研究了国产左炔诺孕酮宫内节育器（LNG，释放速率为6微克/天）对猴子内分泌系统和月经的影响。结果显示，与3只猴子放置节育器前相比，放置后2个排卵周期雌二醇（E2）和孕酮（P）水平显著降低（P>0.001），提示有明显的抑制排卵作用。1只猴子放置前后E2和P水平相同，随后发现该猴子节育器发生脱落。3只动物血浆LNG浓度为493.69 - 454.60皮克/毫升，1只猴子未检测到血浆LNG。取出节育器后激素水平恢复至正常水平。
