Alexeyev O A, Linderholm M, Elgh F, Wadell G, Juto P, Tärnvik A
Department of Virology, Umeå University, Sweden.
Clin Exp Immunol. 1997 Aug;109(2):351-5. doi: 10.1046/j.1365-2249.1997.4641359.x.
In 15 consecutive patients hospitalized with nephropathia epidemica, a European form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus, plasma concentrations of soluble CD23 (sCD23) and Puumala virus-specific IgE were determined. In the acute phase of illness, 11/15 patients had increased sCD23 levels (> 91 U/ml), whereas in convalescence, values of 8/10 patients were normalized. Maximal sCD23 values were correlated to maximal concentrations of Puumala virus-specific serum IgE (r = 0.597; P = 0.025). The results are compatible with a known ability of sCD23 to augment IgE production.
在15例因流行性肾病住院的患者中,流行性肾病是由普马拉病毒引起的一种欧洲型肾综合征出血热(HFRS),测定了可溶性CD23(sCD23)的血浆浓度和普马拉病毒特异性IgE。在疾病急性期,11/15例患者的sCD23水平升高(>91 U/ml),而在恢复期,8/10例患者的值恢复正常。sCD23的最大值与普马拉病毒特异性血清IgE的最大浓度相关(r = 0.597;P = 0.025)。这些结果与sCD23增强IgE产生的已知能力相符。