头颈部滑膜肉瘤：染色体易位（X；18）作为一种诊断辅助手段。
Synovial sarcoma of the head and neck: chromosomal translation (X;18) as a diagnostic aid.
作者信息
Cihak R A, Lydiatt W M, Lydiatt D D, Bridge J A
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center, Omaha 68198-1225, USA.
出版信息
Head Neck. 1997 Sep;19(6):549-53. doi: 10.1002/(sici)1097-0347(199709)19:6<549::aid-hed14>3.0.co;2-0.
BACKGROUND
Synovial sarcoma, a rare tumor in the head and neck, has been historically diagnosed by its characteristic biphasic histologic pattern. Monophasic variants exist which can be difficult to diagnose.
METHODS
Two cases of synovial sarcoma of the head and neck are presented. Both cases, cytogenetic analysis was performed using standard protocols.
RESULTS
Both tumors demonstrated a chromosomal translocation, t(X;18)(p11.2;q11.2), which either made or confirmed the diagnosis.
CONCLUSIONS
Synovial sarcoma contains a characteristic chromosomal translocation which is a useful diagnostic tool, especially when histologic studies are equivocal.
背景
滑膜肉瘤是头颈部罕见肿瘤，以往通过其特征性双相组织学模式进行诊断。存在单相变异型，诊断可能困难。
方法
报告2例头颈部滑膜肉瘤病例。对这2例病例均采用标准方案进行细胞遗传学分析。
结果
2例肿瘤均显示染色体易位t(X;18)(p11.2;q11.2)，该易位有助于做出诊断或确诊。
结论
滑膜肉瘤存在特征性染色体易位，这是一种有用的诊断工具，尤其是在组织学研究结果不明确时。
Zotero 插件