Koga M, Miyata H, Tsuno N, Nakayama K, Ushijima S, Tanaka Y, Hiraga Y, Kobayashi N
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1997 Jun;17(3):143-7.
Distigmine is widely used for the treatment of dysuria, which is caused by various types of psychotropic medications. Distigmine, however, is also known to induce adverse cholinergic effects, such as diarrhea and salivation, with a decreased level of serum cholinesterase. We evaluated the possibility of using serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as specific clinical markers for the adverse cholinergic effects of distigmine. Of the twelve patients treated with distigmine for dysuria caused by psychotropic drugs six patients presented both adverse cholinergic effects and decreased levels of serum AChE and BChE. The other six presented neither of these changes. This study suggests that the values of serum AChE and BChE may be useful markers for the manifestation of adverse cholinergic effects caused by distigmine.
地斯的明广泛用于治疗由各类精神药物引起的排尿困难。然而，地斯的明也会引发不良胆碱能效应，如腹泻和流涎，同时血清胆碱酯酶水平降低。我们评估了将血清乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）用作地斯的明不良胆碱能效应特异性临床标志物的可能性。在12例因精神药物引起排尿困难而接受地斯的明治疗的患者中，6例出现了不良胆碱能效应，且血清AChE和BChE水平降低。另外6例未出现这些变化。本研究表明，血清AChE和BChE的值可能是地斯的明引起的不良胆碱能效应表现的有用标志物。
