Varano M, Billi B, Scassa C, Rossi T, Stirpe M
Fondazione G. B. Bietti per lo Studio e la Ricerca in Oftalmologia, Rome, Italy.
Retina. 1997;17(4):300-5. doi: 10.1097/00006982-199707000-00004.
The purpose of this study was to estimate if and to what extent scanning laser ophthalmoscopy can help in the early diagnosis and follow-up management of the vitreoretinal interface syndrome, which includes disorders such as cellophane maculopathy, pseudomacular hole, macular pucker, and macular hole.
The 35 fellow eyes of 35 patients with vitreoretinal interface syndromes in the first eye underwent scanning laser ophthalmoscopy microperimetry and argon, helium-neon, and infrared scanning laser ophthalmoscopy. Fellow eyes were defined as clinically positive or negative for vitreoretinal interface syndrome. Fellow eyes then were classified based on scanning laser ophthalmoscopy techniques. Patients were observed for an average of 18 months (range, 10-26 months).
Thirty-two of the 35 fellow eyes were classified as clinically negative, and three of the 35 were classified as clinically positive. Fifteen of the 32 clinically negative fellow eyes were redefined as positive on scanning laser ophthalmoscopy. None of the clinically positive eyes proved to be negative on scanning laser ophthalmoscopy. During the average follow-up period (18 months), the condition of five of 18 fellow eyes that were positive on scanning laser ophthalmoscopy worsened. None of the 17 eyes that were negative on scanning laser ophthalmoscopy worsened.
Scanning laser ophthalmoscopy can produce beautifully clear images of structures that are otherwise difficult to see and document, such as posterior hyaloid and the inner retinal layers. Despite a relatively limited number of cases and the short duration of the follow-up period, the present study suggests that scanning laser ophthalmoscopy has good sensitivity and specificity for the early diagnosis of vitreoretinal interface syndromes.
本研究的目的是评估扫描激光检眼镜是否有助于以及在何种程度上有助于玻璃体视网膜界面综合征的早期诊断和随访管理，该综合征包括诸如玻璃纸样黄斑病变、假性黄斑裂孔、黄斑皱褶和黄斑裂孔等病症。
对35例第一眼患有玻璃体视网膜界面综合征患者的35只对侧眼进行扫描激光检眼镜微视野检查以及氩、氦氖和红外扫描激光检眼镜检查。对侧眼被定义为玻璃体视网膜界面综合征临床阳性或阴性。然后根据扫描激光检眼镜技术对这些对侧眼进行分类。患者平均观察了18个月（范围为10 - 26个月）。
35只对侧眼中32只被分类为临床阴性，35只中的3只被分类为临床阳性。32只临床阴性对侧眼中有15只在扫描激光检眼镜检查时被重新定义为阳性。临床阳性眼中没有一只在扫描激光检眼镜检查时被证明为阴性。在平均随访期（18个月）内，扫描激光检眼镜检查阳性的18只对侧眼中有5只病情恶化。扫描激光检眼镜检查阴性的17只眼中没有一只病情恶化。
扫描激光检眼镜能够生成清晰美观的图像，清晰显示诸如后玻璃体膜和视网膜内层等原本难以看清和记录的结构。尽管病例数量相对有限且随访期较短，但本研究表明扫描激光检眼镜对玻璃体视网膜界面综合征的早期诊断具有良好的敏感性和特异性。
