Raval D S, Co S, Reid M A, Pildes R
Steele Memorial Children's Research Center, Department of Pediatrics, The University of Arizona, Tucson 85724, USA.
J Perinatol. 1997 Jul-Aug;17(4):266-9.
Preeclampsia complicated by the HELLP syndrome is associated with poor maternal outcome; there is scant information on neonatal outcome.
To evaluate the outcome of infants born to mothers with HELLP syndrome.
Chart review comparing perinatal variables and the clinical course of 23 infants born to mothers whose pregnancy was complicated with HELLP syndrome (H) with 23 infants of mothers with uncomplicated preeclampsia (P).
Infants in the H group, when compared with those in the P group, had a higher incidence of low Apgar scores (52% vs 18%, p < 0.01), lower admission systolic blood pressure (45 +/- 7 vs 32 +/- 11, p < 0.01), and more frequent need for assisted ventilation (61% vs 30%, p < 0.05). There were no differences between the two groups of infants in hematocrit, leukocyte and platelet count, or duration of ventilation and hospitalization.
These findings suggest that infants born to preeclamptic mothers who develop HELLP syndrome have an increased need for resuscitation at delivery and a higher incidence of postnatal cardiopulmonary instability. Thus mothers with HELLP syndrome should be identified promptly and delivered in level II or III centers with appropriate facilities for management of these newborn infants at risk for perinatal asphyxia and a potential for long-term neurologic sequelae.
子痫前期合并HELLP综合征与孕产妇不良结局相关；关于新生儿结局的信息较少。
评估HELLP综合征母亲所生婴儿的结局。
回顾性分析23例妊娠合并HELLP综合征母亲所生婴儿（H组）与23例子痫前期未合并症母亲所生婴儿（P组）的围产期变量及临床过程。
与P组相比，H组婴儿Apgar评分低的发生率更高（52%对18%，p<0.01），入院时收缩压更低（45±7对32±11，p<0.01），辅助通气需求更频繁（61%对30%，p<0.05）。两组婴儿在血细胞比容、白细胞和血小板计数、通气及住院时间方面无差异。
这些发现提示，子痫前期并发HELLP综合征的母亲所生婴儿出生时复苏需求增加，出生后心肺不稳定发生率更高。因此，应及时识别HELLP综合征母亲，并在具备适当设施的二级或三级中心分娩，以便管理这些有围产期窒息风险及长期神经后遗症可能性的新生儿。
