Heijligenberg R, Romijn J A, Klein S, Endert E, Sauerwein H P
Department of Internal Medicine, Academic Hospital of Amsterdam University.
Am J Clin Nutr. 1997 Sep;66(3):633-8. doi: 10.1093/ajcn/66.3.633.
Lipolysis is higher in patients with acquired immunodeficiency syndrome (AIDS) than in healthy control subjects. To evaluate whether this increase in lipolysis is related to increased beta-adrenergic sensitivity, we compared the lipolytic response to epinephrine (approximately 15 ng x kg(-1) x min(-1)) of six AIDS patients with that of six matched control subjects. Lipolysis was measured by infusion of [2H2]glycerol and [2H2]palmitate. The baseline rates of appearance of palmitate (2.06 +/- 0.21 compared with 1.45 +/- 0.07 micromol x kg(-1) x min(-1)) and glycerol (2.35 +/- 0.16 compared with 1.35 +/- 0.06 micromol x kg(-1) x min(-1)) were higher in AIDS patients (P < 0.05). The absolute increase in lipolysis, an indicator of the responsiveness to epinephrine, was not different between groups for the rate of appearance of palmitate (86 +/- 14 compared with 75 +/- 7 micromol x L(-1) x min(-1)) or glycerol (79 +/- 13 compared with 59 +/- 6 micromol x L(-1) x min(-1)). Plasma concentrations of epinephrine were not different between groups. Lipolysis was higher whereas the lipolytic response to epinephrine was normal in AIDS patients. Increased lipolytic sensitivity to catecholamines is not the cause of increased lipolysis in AIDS.
获得性免疫缺陷综合征（AIDS）患者的脂肪分解水平高于健康对照者。为评估这种脂肪分解增加是否与β-肾上腺素能敏感性增加有关，我们比较了6例AIDS患者与6例匹配对照者对肾上腺素（约15 ng·kg⁻¹·min⁻¹）的脂肪分解反应。通过输注[²H₂]甘油和[²H₂]棕榈酸来测量脂肪分解。AIDS患者棕榈酸（分别为2.06±0.21与1.45±0.07 μmol·kg⁻¹·min⁻¹）和甘油（分别为2.35±0.16与1.35±0.06 μmol·kg⁻¹·min⁻¹）的基线出现率更高（P<0.05）。脂肪分解的绝对增加，即对肾上腺素反应性的指标，在两组之间对于棕榈酸出现率（分别为86±14与75±7 μmol·L⁻¹·min⁻¹）或甘油（分别为79±13与59±6 μmol·L⁻¹·min⁻¹）并无差异。两组之间肾上腺素的血浆浓度无差异。AIDS患者脂肪分解较高，而对肾上腺素的脂肪分解反应正常。对儿茶酚胺的脂肪分解敏感性增加并非AIDS患者脂肪分解增加的原因。
