Morr H
Respiration. 1979;38(3):163-7. doi: 10.1159/000194074.
Human lung tissue passively sensitized with anti-grass pollen IgE antibodies release histamine upon exposure to specific grass pollen antigen. Fenoterol, a beta 2-sympathomimetic stimulator drug, is shown to be a potent inhibitor of antigen-induced release of histamine. This inhibitory effect occurred with fenoterol concentrations of 2 x 10(-8) to 1 x 10(-7) M, and was determined by 67 and 95%, respectively. Thus, the beta 2-receptor stimulator fenoterol is a valuable drug for treating allergic bronchial asthma since it exhibits a combination of prophylactic and direct therapeutic properties.
用抗草花粉IgE抗体被动致敏的人肺组织在接触特定草花粉抗原时会释放组胺。非诺特罗是一种β2 - 拟交感神经刺激剂药物，已被证明是抗原诱导组胺释放的有效抑制剂。这种抑制作用在非诺特罗浓度为2×10(-8)至1×10(-7)M时出现，分别由67%和95%确定。因此，β2受体刺激剂非诺特罗是治疗过敏性支气管哮喘的一种有价值的药物，因为它具有预防和直接治疗特性的组合。
