Wolffe A P, Wong J, Pruss D
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892-5431, USA.
Genes Cells. 1997 May;2(5):291-302. doi: 10.1046/j.1365-2443.1997.1260323.x.
Metazoans and yeast use enzymes that modulate histone acetylation and nucleosomal integrity in order to regulate transcription. Repressor complexes deacetylate histones and stabilize nucleosomes. Activator complexes acetylate histones and disrupt nucleosomes. Variation in chromatin structure makes a major contribution to gene regulation. Here we discuss the enzymatic complexes and molecular machines that make use of chromatin to control transcription.
后生动物和酵母利用调节组蛋白乙酰化和核小体完整性的酶来调控转录。阻遏物复合物使组蛋白去乙酰化并稳定核小体。激活物复合物使组蛋白乙酰化并破坏核小体。染色质结构的变化对基因调控起主要作用。在此，我们讨论利用染色质来控制转录的酶复合物和分子机器。
