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1
Metabolic heterogeneity of nuclear poly (A)-containing RNA in mouse liver.小鼠肝脏中含多聚腺苷酸的核RNA的代谢异质性
Nucleic Acids Res. 1977 Oct;4(10):3473-82. doi: 10.1093/nar/4.10.3473.
2
The relationship between hnRNA+-poly(A) and mRNA+-poly (A) in non-dividing human lymphocytes. Evidence for distinct synthetic pathways for mRNA precursor- and nonprecursor-hnRNA.非分裂人淋巴细胞中核不均一RNA（hnRNA）-聚腺苷酸（poly(A)）与信使RNA（mRNA）-聚腺苷酸（poly(A)）之间的关系。mRNA前体和非前体hnRNA存在不同合成途径的证据。
Biochim Biophys Acta. 1978 Jan 26;517(1):84-98. doi: 10.1016/0005-2787(78)90036-9.
3
The action of cordycepin on nascent nuclear RNA and poly(A) synthesis in regenerating liver.虫草素对再生肝脏中新生核RNA和多聚腺苷酸（poly(A)）合成的作用。
Biochim Biophys Acta. 1976 Jan 19;418(2):160-6. doi: 10.1016/0005-2787(76)90065-4.
4
The stability, polyadenylic acid content and ribonucleoprotein form of nulcear ribonucleic acid in artichoke.洋蓟中核糖核酸的稳定性、聚腺苷酸含量及核糖核蛋白形式
Biochem J. 1976 Dec 1;159(3):585-600. doi: 10.1042/bj1590585.
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Decay of cytoplasmic polyadenylated RNA's labeled with [3H]orotate in rat liver and the effect of the re-utilization of labeled precursor on such decay.用[3H]乳清酸标记的大鼠肝脏细胞质多聚腺苷酸化RNA的衰变以及标记前体的再利用对这种衰变的影响。
Biochemistry. 1977 Jun 28;16(13):3037-44. doi: 10.1021/bi00632a035.
6
[Modification of the half-life of poly (A+)mRNA in liver and brain cells of the rat during embryogenesis and postnatal development].[大鼠胚胎发育和出生后发育过程中肝脏和脑细胞中聚腺苷酸（A+）mRNA半衰期的改变]
Biokhimiia. 1980 Oct;45(10):1886-96.
7
Relationship between nuclear and cytoplasmic poly(adenylic acid).细胞核与细胞质中聚腺苷酸之间的关系。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3580-4. doi: 10.1073/pnas.72.9.3580.
8
Accumulation and decay of messenger ribonucleic acid in mouse kidney.小鼠肾脏中信使核糖核酸的积累与降解
Biochemistry. 1976 Jul 27;15(15):3358-61. doi: 10.1021/bi00660a029.
9
Three mRNA populations differing in turnover and processing in mouse liver.小鼠肝脏中在周转和加工方面存在差异的三种mRNA群体。
Mol Biol Rep. 1975 Dec;2(4):269-75. doi: 10.1007/BF00357013.
10
Effect of tryptophan on polyriboadenylic acid and polyadenylic acid-messenger ribonucleic acid in rat liver.色氨酸对大鼠肝脏中聚核糖核酸和聚腺苷酸-信使核糖核酸的影响。
Lab Invest. 1976 Jan;34(1):77-85.

引用本文的文献

1
Metabolism of poly (A)-containing mRNA in myocardium under normal physiological conditions and compensatory cardiac hyperfunction.正常生理条件下及代偿性心脏功能亢进时心肌中含聚腺苷酸（poly (A)）mRNA的代谢
Basic Res Cardiol. 1981 Mar-Apr;76(2):124-35. doi: 10.1007/BF01907951.

本文引用的文献

1
A NEW METHOD FOR THE DETERMINATION OF THE BASE COMPOSITION OF RIBONUCLEIC ACID.一种测定核糖核酸碱基组成的新方法。
J Biol Chem. 1963 Sep;238:3065-7.
2
Nuclei from rat liver: isolation method that combines purity with high yield.大鼠肝脏细胞核：一种将纯度与高产率相结合的分离方法。
Science. 1966 Dec 30;154(3757):1662-5. doi: 10.1126/science.154.3757.1662.
3
Distribution of radioactivity between the acid-soluble pool and the pools of RNA in the nuclear, nonsedimethable and ribosome fractions of rat liver after a single injection of lebaled orotic acid.单次注射标记乳清酸后，大鼠肝脏核、非沉降及核糖体组分中酸溶性部分与RNA部分之间放射性的分布情况。
Biochim Biophys Acta. 1968 Aug 23;166(1):48-57. doi: 10.1016/0005-2787(68)90489-9.
4
Synthesis and decay rates of major classes of deoxyribonucleic acid a5brandhorst BP, Humphreys T: Synthesis and decay rates of major classes of deoxyribonucleic acid-like ribonucleic acid in sea urchin embryos.脱氧核糖核酸主要类别a5的合成与降解速率 布兰德霍斯特BP，汉弗莱斯T：海胆胚胎中脱氧核糖核酸样核糖核酸主要类别的合成与降解速率
Biochemistry. 1971 Mar 2;10(5):877-81. doi: 10.1021/bi00781a023.
5
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA.海拉细胞信使核糖核酸中富含腺苷酸的序列及其与DNA中重复位点的可能关系。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1321-5. doi: 10.1073/pnas.68.6.1321.
6
Biogenesis and characterization of histone messenger RNA in HeLa cells.HeLa细胞中组蛋白信使核糖核酸的生物合成与特性分析
J Mol Biol. 1972 Jun 28;67(3):397-406. doi: 10.1016/0022-2836(72)90458-5.
7
Synthesis and turnover of nuclear and cytoplasmic polyadenylic acid in mouse L cells.小鼠L细胞中核内和胞质多聚腺苷酸的合成与周转
J Mol Biol. 1974 Jan 25;82(3):315-31. doi: 10.1016/0022-2836(74)90593-2.
8
[Metabolic characteristics of the poly(A) containing mRNA from liver cells].[来自肝细胞的含多聚腺苷酸（poly(A)）mRNA的代谢特征]
Mol Biol. 1974 Nov-Dec;8(6):936-43.
9
Co-existence of non-histone messenger RNA species lacking and containing polyadenylic acid in sea urchin embryos.海胆胚胎中缺乏和含有聚腺苷酸的非组蛋白信使RNA种类的共存。
J Mol Biol. 1974 Nov 5;89(3):435-54. doi: 10.1016/0022-2836(74)90474-4.
10
Relationship of chain transcription to poly(A) addition and processing of hnRNA in HeLa cells.链转录与HeLa细胞中hnRNA的聚腺苷酸化及加工的关系。
Cell. 1974 Nov;3(3):255-64. doi: 10.1016/0092-8674(74)90140-8.

小鼠肝脏中含多聚腺苷酸的核RNA的代谢异质性

Metabolic heterogeneity of nuclear poly (A)-containing RNA in mouse liver.

作者信息

Chernovskaya T V, Lerman M I

出版信息

Nucleic Acids Res. 1977 Oct;4(10):3473-82. doi: 10.1093/nar/4.10.3473.

DOI:10.1093/nar/4.10.3473
PMID:928066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342665/
Abstract

The analysis by the approach to equilibrium labeling method has shown that the poly(A)+ fraction of liver hnRNA is not a uniform class of molecules, but is comprised of two distinct subclasses with half-lives of 5 and 60 min, while the poly(A)- hnRNA was metabolically homogeneous and turned over with a rather uniform half-life of 30 min. The results suggest that (a) poly(A) synthesis and addition is not limiting for the rate of hnRNA processing, and (b) there is a correlation between the kinetics of mRNA appearance in the cytoplasm and kinetic behavior of their possible nuclear precursors.

摘要

通过平衡标记法进行的分析表明，肝脏核内不均一RNA（hnRNA）的聚腺苷酸（poly(A)）+部分不是一类均匀的分子，而是由半衰期分别为5分钟和60分钟的两个不同亚类组成，而聚腺苷酸（poly(A)）- hnRNA在代谢上是均匀的，其周转的半衰期相当一致，为30分钟。结果表明：（a）聚腺苷酸（poly(A)）的合成和添加对hnRNA加工速率没有限制；（b）细胞质中mRNA出现的动力学与其可能的核前体的动力学行为之间存在相关性。