Sandoval C, Fonseca M E, Ochoa R
Hospital de Especialidades Centro Médico Nacional, IMSS, México, D.F.
Ginecol Obstet Mex. 1997 Apr;65:148-51.
Prolactin is a hormone involved in a variety of physiological processes in male and female of several vertebrates species. In mammalian included the human, it has been suggested that prolactin plays a role in immunoregulatory mechanism. There are some evidence in the sense that exists a notable bidirectional interaction between prolactin and the immune systems. This finding has stimulated the research on this area. Prolactin has stimulative effects on the lymphocytes and on the immune responses, and the cytokines production changes the prolactin concentration, so modifying its biological action. These reciprocal effects involve the presence of specific receptors. The prolactin receptors have been demonstrated on lymphocytes and other accessory cells. This review tries to summarize the interaction between immune and neuroendocrine systems and the importance of neuroimmune endocrinologic study.
催乳素是一种参与多种脊椎动物物种雄性和雌性多种生理过程的激素。在包括人类在内的哺乳动物中，有人提出催乳素在免疫调节机制中发挥作用。有一些证据表明催乳素与免疫系统之间存在显著的双向相互作用。这一发现激发了该领域的研究。催乳素对淋巴细胞和免疫反应具有刺激作用，细胞因子的产生会改变催乳素浓度，从而改变其生物学作用。这些相互作用涉及特定受体的存在。催乳素受体已在淋巴细胞和其他辅助细胞上得到证实。本综述试图总结免疫和神经内分泌系统之间的相互作用以及神经免疫内分泌学研究的重要性。
