Schwinger R H, Erdmann E
Klinik III für Innere Medizin, Universität Köln.
Fortschr Med. 1997 Jun 10;115(16):30-4.
Acute cardiac insufficiency is often the result of acute or chronic overloading of the heart due to arterial hypertension, coronary heart disease and/or a reduction in ventricular muscle mass following myocardial infarction. Whenever possible, treatment should be causal (e.g. treatment of hypertension, operative correction of valvular disease). While the incidence of heart failure continues to increase, morbidity and mortality associated with the disease process have remained essentially unchanged. About 30% of the patients die within the first 12 months. The prognosis and outcome of heart failure patients strongly correlate with markers of neuroendocrine activation. While numerous drugs are capable of improving hemodynamics at rest or physical performance, they fall to prolong survival. It is hoped, that new pathophysiological information might lead to the development of new, effective therapeutic approaches.
急性心功能不全通常是由动脉高血压、冠心病和/或心肌梗死后心室肌肉质量减少导致的心脏急性或慢性负荷过重引起的。只要有可能，治疗应针对病因（如治疗高血压、手术纠正瓣膜疾病）。虽然心力衰竭的发病率持续上升，但与该疾病过程相关的发病率和死亡率基本保持不变。约30%的患者在最初12个月内死亡。心力衰竭患者的预后和结局与神经内分泌激活标志物密切相关。虽然许多药物能够改善静息时的血流动力学或身体机能，但它们并不能延长生存期。人们希望，新的病理生理学信息可能会带来新的有效治疗方法的发展。
