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[患有颈动脉狭窄且冠心病临床病史为阴性的患者。运动试验对识别缺血性心肌病的有用性]

[Patients with carotid stenosis and clinical history negative for coronary disease. Usefulness of the ergometric test for the identification of ischemic myocardial disease].

作者信息

Sconocchini C, Racco F, Pratillo G, Alesi C, Zappelli L

机构信息

Ospedale di Jesi, Divisione di Neurologia, Ancona.

出版信息

Minerva Med. 1997 May;88(5):173-81.

PMID:9280860
Abstract

BACKGROUND

The purpose of this study was to evaluate, by Stress-Exercise Electrocardiography (SE), the presence of Coronary Artery Disease (CAD) in patients with asymptomatic or symptomatic carotid stenosis, who had no history of myocardial ischemia.

MATERIALS, METHODS AND RESULTS: 133 patients with significant carotid stenosis (> = 50%) were consecutively studied according to an established vascular protocol. Of 92 patients with no history of CAD, 3 were excluded, 4 with bilateral carotid occlusion underwent an Echocardiography-Stress Test with Dipyridamole (ED) with negative result. 85 patients underwent a SE. The result was negative in 50 patients, positive in 21. In 14 patients the SE was uncertain so that they underwent an ED or stress thallium-201 myocardial scintigraphy with positive result in 2. No correlation between the degree of carotid stenosis and the positive SE in patients with significant carotid artery atherosclerosis was found.

CONCLUSIONS

Our study demonstrates that about 25% of patients with significant asymptomatic and symptomatic carotid stenosis and no history of CAD had a latent myocardial ischemia and that the screening of these patients with SE is easy, inexpensive and safe and allow us to detect those who need a more active treatment.

摘要

背景

本研究旨在通过应激运动心电图(SE)评估无症状或有症状的颈动脉狭窄且无心肌缺血病史患者中冠状动脉疾病(CAD)的存在情况。

材料、方法与结果:根据既定的血管检查方案,对133例有显著颈动脉狭窄(≥50%)的患者进行了连续研究。在92例无CAD病史的患者中,3例被排除,4例双侧颈动脉闭塞患者接受了双嘧达莫超声心动图应激试验(ED),结果为阴性。85例患者接受了SE检查。50例结果为阴性,21例为阳性。14例患者的SE结果不确定,因此他们接受了ED或应激铊-201心肌闪烁显像检查,其中2例结果为阳性。在有显著颈动脉粥样硬化的患者中,未发现颈动脉狭窄程度与SE阳性之间存在相关性。

结论

我们的研究表明,约25%有显著无症状和有症状颈动脉狭窄且无CAD病史的患者存在潜在心肌缺血,并且用SE对这些患者进行筛查简便、廉价且安全,能够让我们检测出那些需要更积极治疗的患者。

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