Gracia F, Castillo L C
Sección de Neurología del Hospital Santo Tomás.
Rev Med Panama. 1996 Sep;21(3):121-31.
Dystonia is a neurologic disease characterized by involuntary repetitive muscular contractions which frequently causes torsion, spasmodic movements or abnormal postures. Pharmacologic and surgical treatment had been unsatisfactory in the majority of the cases. Intramuscular botulinic toxin application in focal dystonia disorders, achieve relief in approximately 90% of the cases by quimiodenervation. We included 35 patients with focal dystonia treated between November 1994 through June 1996: 14 facial hemispasm, nine blepharospasm, five cervical dystonia, two writer's cramps, one oromandibular dystonia and four patients with mixed focal dystonia. Improvement between 50-90% was observed in 32/34 (94%) of the patients; one case (2.8%) with therapeutic failure and one case (2.8%) never returned to quantify the response. Actually, botulinic toxin is the first choice treatment of focal dystonia and other diseases related to involuntary muscle spasm.
肌张力障碍是一种神经系统疾病，其特征为不自主的重复性肌肉收缩，常导致扭转、痉挛性运动或异常姿势。在大多数病例中，药物和手术治疗效果均不理想。在局灶性肌张力障碍疾病中，肌肉注射肉毒毒素通过化学去神经作用，约90%的病例可获得缓解。我们纳入了1994年11月至1996年6月间接受治疗的35例局灶性肌张力障碍患者：14例为面肌痉挛，9例为眼睑痉挛，5例为颈部肌张力障碍，2例为书写痉挛，1例为口下颌肌张力障碍，4例为混合型局灶性肌张力障碍。32/34（94%）的患者改善率在50%至90%之间；1例（2.8%）治疗失败，1例（2.8%）未复诊以评估疗效。实际上，肉毒毒素是局灶性肌张力障碍及其他与不自主肌肉痉挛相关疾病的首选治疗方法。
