Beyer C, González-Flores O, González-Mariscal G
Centro de Investigación en Reproducciön Animal, CINVESTAV-UniversidadAutónoma de Tlaxcala, Mexico.
J Neuroendocrinol. 1997 Aug;9(8):609-14. doi: 10.1046/j.1365-2826.1997.00617.x.
We explored the effect of the antiprogestin RU486 on the estrous behaviour (lordosis and proceptivity) induced in sexually experienced ovariectomized oestrogen primed rats by: 5 microg luteinizing hormone-releasing hormone (LHRH), 100 microg prostaglandin E2 (PGE2), or 2 mg dibutyryl cyclic AMP (db cAMP). Pretreatment with 5 mg RU 486 (but not with vehicle) 60 min before the injection of the above-mentioned agents significantly decreased both lordosis and proceptive behaviours normally induced by such agents. Results suggest that the estrus-inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.
我们通过以下方式研究了抗孕激素RU486对性经验丰富的去卵巢并用雌激素预处理的大鼠中由5微克促黄体生成激素释放激素（LHRH）、100微克前列腺素E2（PGE2）或2毫克二丁酰环磷腺苷（db cAMP）诱导的发情行为（脊柱前凸和接受性）的影响。在注射上述药物前60分钟用5毫克RU 486（而非赋形剂）预处理，可显著降低此类药物通常诱导的脊柱前凸和接受性行为。结果表明，LHRH、PGE2和db cAMP的诱情作用是通过激活孕酮受体实现的。
