Pertynski T, Ketkar M B, Mariss P, Reznik G, Hassenstein E, Nüsslin F, Dieffenbach G, Haindl H
Strahlentherapie. 1979 Nov;155(11):770-3.
Squamous cell carcinoma was induced in male 6 to 8-week old NMRI-mice by application of 9,10-dimethyl-1,2-benzanthracene on the skin. 15 weeks later macroscopically visible skin tumors are developed. Then organ distribution and tumor accumulation of 57Co-Bleomycin (spec. activity 1 mCi/3.3 mg) were studied 1 to 48 hours after injection. In squamous cell carcinoma a high uptake of this tumor-seeking agent can be demonstrated (n = 46). After radiotherapy (100 kV; 1.7 mm Al-filter; 18.8 Gy) (n = 26), however, a significantly reduced uptake of 57Co-Bleomycin in tumor tissue is observed. Possible consequences from these animal studies for tumor scintigraphy with this radiopharmaceutical in man are discussed.
通过在6至8周龄雄性NMRI小鼠的皮肤上涂抹9,10 - 二甲基 - 1,2 - 苯并蒽诱导鳞状细胞癌。15周后出现肉眼可见的皮肤肿瘤。然后在注射57Co - 博来霉素（比活度1 mCi/3.3 mg）后1至48小时研究其器官分布和肿瘤蓄积情况。在鳞状细胞癌中可证明该肿瘤寻踪剂有高摄取（n = 46）。然而，在放疗（100 kV；1.7 mm铝滤过器；18.8 Gy）后（n = 26），观察到肿瘤组织中57Co - 博来霉素的摄取显著降低。讨论了这些动物研究对该放射性药物在人体肿瘤闪烁扫描中的可能影响。
