[Distribution studies of 111In labeled bleomycin in the intratumoral and peritumoral treatment of advanced squamous cell carcinomas in the oto-rhino-larygnological region (author's transl)].

The localization of 111In labeled Bleomycin was studied in 9 patients with advanced squamous cell carcinomas. The dosis was injected either peritumorally or intramorally. Accumulation of Radiobleomycin in tumor tissue, in blood and in urine was tested. We found a very high accumulation in tumor tissue for a short time within 2 hours, a very rapid excretion of Radiobleomycin in urine and concomitant slowly decrease of 111In Bleomycin in blood was observed.