[Sensitivity of the isolated adipose tissue to insulin in obesity with presence or absence of diabetes mellitus].

The authors studied the sensitivity of the isolated adipose tissue to various insulin concentrations in healthy women and also in women suffering from adiposity with the normal and diabetic test for glucose tolerance. Adipose tissue sensitivity to insulin was studied by the influence of insulin to the intensity of incorporation of carbohydrate of labeled glucose into the common lipids of the adipose tissue in its incubation with various insulin concentrations. A marked reduction of the adipose tissue sensitivity to physiological concentrations of insulin was shown in patients with adiposity. The extent of insulin sensitivity fall was the same in such patients with normal glucose tolerance and in those suffering from latent diabetes. A conclusion was drawn that the mentioned reduction of adipose tissue sensitivity to insulin could serve as a significant factor leading to the development of diabetic disturbances in adiposity. Another factor playing an important role in the development of diabetic disturbances in adiposity was compensatory possibilities of beta-cells of the pancreas.