Vaden S L
Department of Companion Animal and Special Species Medicine, North Carolina State University, College of Veterinary Medicine, Raleigh 27606, USA.
Semin Vet Med Surg Small Anim. 1997 Aug;12(3):161-6. doi: 10.1016/s1096-2867(97)80028-x.
Cyclosporine and tacrolimus are potent immunosuppressant agents that have been used extensively in humans, primarily for prevention of transplant rejection but also for the treatment of autoimmune disorders. Both agents have similar mechanisms of action and pharmacokinetic profiles. However, the expected toxicity of the agents is dissimilar. Although cyclosporine usage in veterinary medicine is limited, it has been used enough for therapeutic guidelines to be established. Tacrolimus, however, has undergone limited use in veterinary medicine. The drug is too toxic in dogs for its use to be recommended in most clinical situations. This article reviews the mechanism of action, pharmacokinetics, expected drug interactions and toxicities, and clinical usage of cyclosporine and tacrolimus in veterinary medicine.
环孢素和他克莫司是强效免疫抑制剂，已在人类中广泛使用，主要用于预防移植排斥反应，但也用于治疗自身免疫性疾病。这两种药物具有相似的作用机制和药代动力学特征。然而，这两种药物的预期毒性不同。尽管环孢素在兽医学中的使用有限，但已使用到足以建立治疗指南的程度。然而，他克莫司在兽医学中的使用有限。该药物对犬类毒性太大，在大多数临床情况下不建议使用。本文综述了环孢素和他克莫司在兽医学中的作用机制、药代动力学、预期的药物相互作用和毒性以及临床应用。
