Macy D W
Department of Clinical Sciences, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins 80523, USA.
Semin Vet Med Surg Small Anim. 1997 Aug;12(3):206-11. doi: 10.1016/s1096-2867(97)80034-5.
Vaccine adjuvants provide enhanced immune responses to a variety of antigens. Unlike human vaccines that are limited to aluminum-based adjuvants, veterinary vaccines may contain a large number of substances either alone or in combination that act as vaccine adjuvants. Although the use of adjuvants in veterinary vaccines enhances the immunogenicity of vaccines, they have been responsible for a number of side effects. This article explores the rationale of currently used vaccine adjuvants and some of the adverse events associated with their use in veterinary medicine.
疫苗佐剂可增强对多种抗原的免疫反应。与限于铝基佐剂的人类疫苗不同,兽用疫苗可能单独或组合含有大量用作疫苗佐剂的物质。虽然在兽用疫苗中使用佐剂可增强疫苗的免疫原性,但它们也导致了一些副作用。本文探讨了当前使用的疫苗佐剂的基本原理以及与它们在兽医学中的使用相关的一些不良事件。