Wilson J F
Department of Psychology, Wittenberg University, Springfield, OH 45501, USA.
Physiol Behav. 1997 Oct;62(4):779-82. doi: 10.1016/s0031-9384(97)00235-7.
To assess the effects of various low-protein diets on the eating behavior of female rats, 280 rats were assigned to one of 20 groups, according to a 5 x 2 x 2 (Protein Level x Pregnancy x Sugar) design. Each rat was offered one of five isocaloric, soy-based diets: 25%, 8%, 4%, 2% or 1% protein diet. The subjects' intakes and weights were recorded daily for 3 weeks. Protein content of the diet, pregnancy, and the presence of dietary sucrose all had significant effects on diet, sucrose, and protein intake. By the third week of the experiment, pregnant rats offered 1%, 2% or 4% protein diets consumed significantly less of their diet than did their nonpregnant controls, whereas pregnant rats in the 25% protein group consumed significantly more of their diet than did nonpregnant controls. The eating behavior of the rats offered the 8% protein diet was most affected by the presence of dietary sucrose. Pregnant rats in the 8% protein group consumed less of their diet than did nonpregnant controls when sucrose was also offered, but they consumed more of their diet than did nonpregnant controls when sucrose was not offered. A learned food aversion is probably the best explanation for the severe reduction of diet intake observed in pregnant rats in all of the 1%, 2%, and 4% protein groups, as well as in pregnant rats offered the 8% protein diet and sucrose.
为评估不同低蛋白饮食对雌性大鼠进食行为的影响，根据5×2×2（蛋白质水平×妊娠×糖）设计，将280只大鼠分配到20个组中的一组。给每只大鼠提供五种等热量、以大豆为基础的饮食之一：25%、8%、4%、2%或1%蛋白质饮食。每天记录实验对象的摄入量和体重，为期3周。饮食中的蛋白质含量、妊娠情况以及饮食中蔗糖的存在对饮食、蔗糖和蛋白质摄入量均有显著影响。到实验第三周时，摄入1%、2%或4%蛋白质饮食的怀孕大鼠比未怀孕的对照大鼠饮食摄入量显著减少，而摄入25%蛋白质组的怀孕大鼠比未怀孕的对照大鼠饮食摄入量显著增加。提供8%蛋白质饮食的大鼠的进食行为受饮食中蔗糖存在的影响最大。当也提供蔗糖时，8%蛋白质组的怀孕大鼠比未怀孕的对照大鼠饮食摄入量少，但当不提供蔗糖时，它们比未怀孕的对照大鼠饮食摄入量多。习得性食物厌恶可能是所有1%、2%和4%蛋白质组的怀孕大鼠以及提供8%蛋白质饮食和蔗糖的怀孕大鼠饮食摄入量严重减少的最佳解释。
