Breitburd F, Ramoz N, Salmon J, Orth G
Unité Mixte Institut Pasteur/INSERM (U190), Institut Pasteur, Paris, France.
Semin Cancer Biol. 1996 Dec;7(6):359-71. doi: 10.1006/scbi.1996.0045.
Cellular immunity is likely to be of major importance for the clearance of inapparent or overt infections caused by human papillomaviruses (HPVs). The highly polymorphic class I or class II human leukocyte antigen (HLA) molecules present HPV-derived peptides to cytotoxic (CD8+) or helper (CD4+) T lymphocytes bearing specific receptors and condition the immune responsiveness to HPV infections. Recent data point to a role of an altered expression of HLA molecules in the persistence of HPV-induced cervical premalignant lesions and their progression towards invasive carcinoma. Furthermore positive of negative associations of certain HLA alleles or haplotypes with cutaneous of cervical neoplasias have been found. These observations may have important implications in the design of therapy or vaccines aimed at eradicating cervical cancer.
细胞免疫对于清除由人乳头瘤病毒（HPV）引起的隐性或显性感染可能至关重要。高度多态性的I类或II类人类白细胞抗原（HLA）分子将HPV衍生的肽呈递给携带特异性受体的细胞毒性（CD8 +）或辅助性（CD4 +）T淋巴细胞，并调节对HPV感染的免疫反应性。最近的数据表明，HLA分子表达改变在HPV诱导的宫颈癌前病变持续存在及其向浸润性癌进展中起作用。此外，还发现某些HLA等位基因或单倍型与皮肤或宫颈肿瘤形成存在正相关或负相关。这些观察结果可能对旨在根除宫颈癌的治疗或疫苗设计具有重要意义。
