Barreca T, Franceschini R, Pellicci R, Carozzi S, Bruno E, Dardano G, Rolandi E, Valente U
Dipartimento di Medicina Interna, Università di Genova, Italy.
Metabolism. 1997 Sep;46(9):1003-7. doi: 10.1016/s0026-0495(97)90269-9.
Ten liver transplant patients were studied in basal conditions and after ingestion of a standard mixed test meal. Control groups included 10 normal subjects, 10 patients with nonalcoholic liver cirrhosis, and seven kidney transplant patients. Plasma somatostatin, blood glucose, and plasma insulin, C-peptide, and glucagon were determined before and 15, 30, 45, 60, 90, 120, and 180 minutes after the start of the meal. In liver transplant patients, basal somatostatin and insulin levels were significantly lower than in cirrhotics and were comparable to those recorded in controls and in kidney transplant patients. The time course of the somatostatin secretory response after the meal was similar in any group, but the increase, evaluated as the incremental area above baseline, was significantly higher in liver transplant patients than in controls and cirrhotics and comparable to that recorded in kidney transplant patients. Insulin incremental areas were also lower than in cirrhotics and comparable to those recorded in controls and kidney transplant patients. The data suggest that in liver transplant patients an increased somatostatin response to a meal may be related to a relative beta-cell secretory defect, which in turn seems consequent to immunosuppressive treatment.
对10例肝移植患者在基础状态下以及摄入标准混合试验餐后进行了研究。对照组包括10名正常受试者、10例非酒精性肝硬化患者和7例肾移植患者。在进餐开始前以及开始后15、30、45、60、90、120和180分钟测定血浆生长抑素、血糖、血浆胰岛素、C肽和胰高血糖素。在肝移植患者中，基础生长抑素和胰岛素水平显著低于肝硬化患者，与对照组和肾移植患者所记录的水平相当。餐后生长抑素分泌反应的时间进程在任何组中都相似，但以基线以上的增量面积评估，肝移植患者的增加幅度显著高于对照组和肝硬化患者，与肾移植患者所记录的相当。胰岛素增量面积也低于肝硬化患者，与对照组和肾移植患者所记录的相当。数据表明，在肝移植患者中，进餐时生长抑素反应增加可能与相对的β细胞分泌缺陷有关，而这反过来似乎是免疫抑制治疗的结果。
