Barreca T, Franceschini R, Messina V, Cataldi A, Salvemini M, Rolandi E
Scientific Institute of Internal Medicine, University of Genoa, Italy.
Horm Res. 1989;31(5-6):234-7. doi: 10.1159/000181123.
Ten obese and 10 control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Blood glucose, insulin, somatostatin (SLI) and vasoactive intestinal polypeptide (VIP) concentrations were determined before and 30, 60, 90, 120, 180 and 240 min after the start of the meal. Basal SLI levels in the obese (14.4 +/- 0.7 ng/l) were not significantly different from those in the controls (15.5 +/- 0.8 ng/l), whereas after the meal a blunted secretory response was recorded. Baseline plasma VIP levels were higher in the obese (29.7 +/- 1.5 ng/l) than in the control subjects (19.8 +/- 1.3 ng/l) and, similarly to the controls, were unaffected by meal ingestion. Data suggest that in the course of obesity an enhanced VIP secretion in association with a diminished SLI responsiveness to meals occurs.
对10名肥胖受试者和10名对照受试者在基础状态下以及摄入标准混合测试餐后进行了研究。在进餐开始前以及开始后30、60、90、120、180和240分钟测定血糖、胰岛素、生长抑素（SLI）和血管活性肠肽（VIP）浓度。肥胖受试者的基础SLI水平（14.4±0.7 ng/l）与对照受试者（15.5±0.8 ng/l）无显著差异，而餐后记录到分泌反应减弱。肥胖受试者的基线血浆VIP水平（29.7±1.5 ng/l）高于对照受试者（19.8±1.3 ng/l），并且与对照受试者一样，不受进餐摄入的影响。数据表明，在肥胖过程中，会出现与生长抑素对进餐反应性降低相关的血管活性肠肽分泌增强。
