Tupler L A, Davidson J R, Smith R D, Lazeyras F, Charles H C, Krishnan K R
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Biol Psychiatry. 1997 Sep 15;42(6):419-24. doi: 10.1016/S0006-3223(96)00501-X.
Peak spectral amplitudes for choline moieties (Cho), creatine (Cr), N-acetylaspartate (NAA), and myo-inositol (mI) were examined using proton magnetic resonance spectroscopy in 19 social-phobia patients and 10 controls. Compared with controls, social phobics demonstrated significantly lower NAA/Cho and higher Cho/Cr, mI/Cr, and mI/NAA amplitudes in cortical gray matter. Higher mI/Cr and mI/NAA amplitudes for social phobics were also observed in subcortical gray matter. Minimal between-group differences were noted for white matter. Symptom severity correlated inversely with amplitudes primarily in subcortical gray matter, and to a lesser extent in cortical gray matter. Inclusion of age and sex in statistical modeling strengthened comparisons with controls but eliminated those for symptom severity. No changes were observed in any amplitude measure following at least 8 weeks of clonazepam treatment, nor was a relationship observed between amplitudes and cumulative clonazepam dose. The possible psychobiological implications of our findings in social phobia are discussed.
使用质子磁共振波谱对19例社交恐惧症患者和10名对照者的胆碱部分（Cho）、肌酸（Cr）、N-乙酰天门冬氨酸（NAA）和肌醇（mI）的峰值光谱幅度进行了检测。与对照者相比，社交恐惧症患者皮质灰质中的NAA/Cho显著降低，而Cho/Cr、mI/Cr和mI/NAA幅度更高。在皮质下灰质中也观察到社交恐惧症患者的mI/Cr和mI/NAA幅度更高。白质的组间差异最小。症状严重程度主要与皮质下灰质的幅度呈负相关，在皮质灰质中的相关性较小。在统计模型中纳入年龄和性别加强了与对照者的比较，但消除了症状严重程度的比较。氯硝西泮治疗至少8周后，任何幅度测量均未观察到变化，幅度与氯硝西泮累积剂量之间也未观察到相关性。讨论了我们在社交恐惧症中的发现可能具有的心理生物学意义。
