Rosen R C
Department of Psychiatry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, USA.
Blood Press Suppl. 1997;1:47-51.
Sexual dysfunction has been identified in numerous controlled trials to be a frequent accompaniment to antihypertensive therapy. Issues of cause and effect are confused because hypertension itself can cause sexual dysfunction. It seems probable, however, that use of certain classes of blood pressure-lowering agents, notably non-cardioselective beta blockers such as propranolol, thiazide diuretics such as chlorthalidone and centrally-acting adrenergic agonists, is associated with an increased risk of sexual dysfunction. The implications of these data for compliance with antihypertensive therapy are considered.
在众多对照试验中已确定性功能障碍是抗高血压治疗常见的伴随症状。因果关系问题较为复杂，因为高血压本身就可能导致性功能障碍。然而，使用某些种类的降压药物，尤其是非心脏选择性β受体阻滞剂（如普萘洛尔）、噻嗪类利尿剂（如氯噻酮）和中枢作用的肾上腺素能激动剂，似乎会增加性功能障碍的风险。文中考虑了这些数据对高血压治疗依从性的影响。
