Prisant L M, Carr A A, Bottini P B, Solursh D S, Solursh L P
Department of Medicine, Medical College of Georgia, Augusta.
Arch Intern Med. 1994 Apr 11;154(7):730-6.
The relationship of antihypertensive drugs have a long history of association with sexual dysfunction; however, this relationship is poorly documented. There appears to be a higher rate of sexual dysfunction in untreated hypertensive men compared with normotensive men. Sexual dysfunction increases with age and is associated with physical and emotional symptoms. There are few studies assessing sexual dysfunction with female and African-American hypertensive patients. Sexual dysfunction is associated with impairment of quality of life and noncompliance. Since group data may hide individual drug effects, baseline data should be collected on all patients before initiating therapy with any antihypertensive agent. Although questionnaires may not provide objective information on sexual dysfunction, the response rate to direct questioning may be less than the response rate on a questionnaire and may be affected by the gender or race of the interviewer. Research protocols using a double-blind, placebo-controlled design should assess sexual dysfunction in men and women in a standardized fashion.
抗高血压药物与性功能障碍之间的关联由来已久；然而，这种关联的文献记载并不充分。与血压正常的男性相比，未经治疗的高血压男性出现性功能障碍的比例似乎更高。性功能障碍会随着年龄增长而增加，并且与身体和情绪症状相关。评估女性和非裔美国高血压患者性功能障碍的研究较少。性功能障碍与生活质量受损和治疗依从性差有关。由于群体数据可能掩盖个体药物效应，因此在开始使用任何抗高血压药物治疗之前，都应收集所有患者的基线数据。尽管问卷调查可能无法提供关于性功能障碍的客观信息，但直接询问的回应率可能低于问卷调查的回应率，并且可能受到访谈者性别或种族的影响。采用双盲、安慰剂对照设计的研究方案应以标准化方式评估男性和女性的性功能障碍。
