Miossec P
Department of Immunology, Hôpital Edouard Herriot, Lyon, France.
Drug Saf. 1997 Aug;17(2):93-104. doi: 10.2165/00002018-199717020-00002.
Cytokines are now commonly used in the treatment of many conditions, especially cancer, haematological malignancies and chronic viral hepatitis. With some of these cytokines, clinical induction and/or exacerbation of autoimmune manifestations have been observed. This has been the case with interferon-alpha and interferon-gamma, interleukin-2 and some colony-stimulating factors. All known biological and clinical autoimmune features have been observed but thyroid abnormalities have been particularly frequent. Some of these manifestations appear to be related to the effect of these exogenous cytokines on the T helper cell (TH) 1/TH2-cytokine balance and the regulatory properties of these cells. Patients with a history of underlying autoimmune disease or baseline serological abnormalities should be monitored for autoimmunity when treated with certain TH1 or TH2-inducing cytokines.
细胞因子目前常用于多种病症的治疗，尤其是癌症、血液系统恶性肿瘤和慢性病毒性肝炎。在使用某些细胞因子时，已观察到自身免疫表现的临床诱导和/或加重情况。α干扰素、γ干扰素、白细胞介素-2和一些集落刺激因子就是如此。已观察到所有已知的生物学和临床自身免疫特征，但甲状腺异常尤为常见。其中一些表现似乎与这些外源性细胞因子对辅助性T细胞（TH）1/TH2细胞因子平衡以及这些细胞的调节特性的影响有关。有潜在自身免疫疾病病史或基线血清学异常的患者在使用某些诱导TH1或TH2的细胞因子进行治疗时，应监测其自身免疫情况。
