Buchholz B A, Pawley N H, Vogel J S, Mauthe R J
Lawrence Livermore National Laboratory, CA 94551, USA.
J Appl Toxicol. 1997 Jul-Aug;17(4):231-4. doi: 10.1002/(sici)1099-1263(199707)17:4<231::aid-jat434>3.0.co;2-j.
We studied the effect of pyridostigmine bromide, a nerve agent prophylactic, on the central nervous system (CNS) uptake of [14C]permethrin, a pyrethroid insecticide, at scaled human-equivalent exposures in rats using accelerator mass spectrometry (AMS). AMS detects 14C at attomole sensitivities and determines the tissue distribution of 14C-labeled compounds. Pyridostigmine bromide in chow at 7.75 mg kg(-1) per day lowered the CNS tissue levels of permethrin, dosed at 4.75 microg kg(-1), in the CNS of rats by 30%. These results are inconsistent with hypothesized synergy of such compounds as a precursor to 'Gulf War syndrome'.
我们使用加速器质谱法（AMS），在大鼠身上模拟人体等效暴露剂量，研究了神经毒剂预防药物溴吡斯的明对拟除虫菊酯类杀虫剂[14C]氯菊酯中枢神经系统（CNS）摄取的影响。AMS能以阿托摩尔灵敏度检测14C，并确定14C标记化合物的组织分布。每天在食物中添加7.75毫克/千克的溴吡斯的明，可使以4.75微克/千克剂量给药的氯菊酯在大鼠中枢神经系统中的组织水平降低30%。这些结果与将此类化合物的协同作用假设为“海湾战争综合征”前兆的观点不一致。
