Cell polarity: par for the polar course.

作者信息

Nelson W J, Grindstaff K K

机构信息

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5426, USA.

出版信息

Curr Biol. 1997 Sep 1;7(9):R562-4. doi: 10.1016/s0960-9822(06)00282-x.

The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.