Rükgauer M, Klein J, Kruse-Jarres J D
Institute for Clinical Chemistry and Laboratory Medicine, Katharinenhospital, Stuttgart, Germany.
J Trace Elem Med Biol. 1997 Jun;11(2):92-8. doi: 10.1016/S0946-672X(97)80032-6.
Up to now few plasma or serum reference or serum reference values have been available for the assessment of the essential trace element supply status in different age groups covering the whole range of life range. In the present investigation, the concentrations of copper, manganese, selenium, and zinc were determined in the serum of 137 healthy children and in the plasma of 68 blood-donors. The age distribution within these groups ranged from 1 month to 18 years and from 22 to 75 years. The determinations were carried out directly by means of electrothermal atomic absorption spectrophotometry with Zeeman background compensation. The adult plasma reference values (mean +/- 2 SD) were 1.65 +/- 8.6 mumol/1 for copper, 14.3 +/- 11.4 nmol/1 for manganese, 0.80 +/- 0.36 mumol/1 for selenium, and 16.6 +/- mumol/1 for zinc. No correlation between concentration of elements and sex could be established. In the child and adolescent group, the manganese levels exhibited an age-dependent linear decrease (54% of the starting value, slope 0.92, r = 0.4, p < 0.001), the copper and the selenium concentrations, respectively, exhibited an exponential increase (107%, r = 0.59 and 174%, r = 0.61), with the highest value in the age group of 6 to 10 years. Reference ranges are established for 9 different age groups. The results reflect the known physiological data on the trace element content in the tissue of children and their diet. The present study is an important pre-requisite for diagnosis and therapy of trace element deficiencies in all age groups.
到目前为止，几乎没有血浆或血清参考值可用于评估涵盖整个生命范围的不同年龄组的必需微量元素供应状况。在本研究中，测定了137名健康儿童血清和68名献血者血浆中铜、锰、硒和锌的浓度。这些组的年龄分布范围为1个月至18岁以及22岁至75岁。测定是通过带有塞曼背景校正的电热原子吸收分光光度法直接进行的。成人血浆参考值（均值±2标准差）铜为1.65±0.86μmol/L，锰为14.3±11.4nmol/L，硒为0.80±0.36μmol/L，锌为16.6±μmol/L。未发现元素浓度与性别之间存在相关性。在儿童和青少年组中，锰水平呈现出与年龄相关的线性下降（起始值的54%，斜率0.92，r = 0.4，p < 0.001），铜和硒浓度分别呈现指数增长（107%，r = 0.59和174%，r = 0.61），在6至10岁年龄组中达到最高值。为9个不同年龄组建立了参考范围。结果反映了关于儿童组织中微量元素含量及其饮食的已知生理数据。本研究是所有年龄组微量元素缺乏症诊断和治疗的重要前提条件。
