Pappo A S, Shapiro D N, Crist W M
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pediatr Clin North Am. 1997 Aug;44(4):953-72. doi: 10.1016/s0031-3955(05)70539-3.
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Recognition of specific genetic changes in the two most common subtypes of rhabdomyosarcoma has allowed better understanding of the pathogenesis of this disease. In addition, identification of prognostic factors and the use of risk-directed multimodal therapy have improved the outcome for these patients significantly, with cure rates approaching 70%.
横纹肌肉瘤是儿童最常见的软组织肉瘤。对横纹肌肉瘤两种最常见亚型中特定基因变化的认识，使人们对这种疾病的发病机制有了更好的理解。此外，预后因素的确定以及风险导向的多模式治疗的应用，显著改善了这些患者的治疗结果，治愈率接近70%。
