Pappo A S
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318, USA.
Curr Opin Oncol. 1995 Jul;7(4):361-6. doi: 10.1097/00001622-199507000-00012.
This review of the past year's literature summarizes the most relevant advances in the biology and therapy of rhabdomyosarcoma and other pediatric soft tissue sarcomas. The results of the third Intergroup Rhabdomyosarcoma Study clearly show that therapy based on specific risk factors offers the best chance of cure for children with rhabdomyosarcoma. The recent identification of nonrandom chromosomal translocations within distinct histologic subtypes of rhabdomyosarcoma and nonrhabdomyosarcoma soft tissue sarcomas offers a unique opportunity to improve our ability to diagnose, stage, and monitor these patients. Finally, identification of the genetic features that characterize these tumors will help us better understand the mechanisms involved in tumorigenesis and will facilitate the development of novel specific therapies.
这篇对过去一年文献的综述总结了横纹肌肉瘤及其他小儿软组织肉瘤在生物学和治疗方面最相关的进展。第三届横纹肌肉瘤协作组研究结果清楚表明，基于特定风险因素的治疗为患有横纹肌肉瘤的儿童提供了最佳治愈机会。最近在横纹肌肉瘤及非横纹肌肉瘤软组织肉瘤的不同组织学亚型中发现非随机染色体易位，为提高我们诊断、分期和监测这些患者的能力提供了独特机会。最后，确定这些肿瘤的基因特征将有助于我们更好地理解肿瘤发生所涉及的机制，并将促进新型特异性疗法的开发。
