Melo R A, Garcia A B, Viana S R, Falcão R P
Department of Clinical Medicine, School of Medicine, Riberiräo Preto, Brazil.
Acta Haematol. 1997;98(2):72-5. doi: 10.1159/000203595.
The distribution of lymphocyte subsets in blood, thymus, spleen, mesenteric lymph nodes, Peyer's patches and bone marrow was evaluated in an experimental model of secondary hemochromatosis in rats. The values of CD2, CD4, CD8, B and NK cells in these different lymphoid compartments did not differ between the control group and the experimental group. These results suggest that the abnormalities of lymphocyte subsets previously reported in patients with secondary hemochromatosis may be due to factors other than iron overload.
在大鼠继发性血色素沉着症的实验模型中，评估了血液、胸腺、脾脏、肠系膜淋巴结、派尔集合淋巴结和骨髓中淋巴细胞亚群的分布。在这些不同淋巴区室中，对照组和实验组的CD2、CD4、CD8、B细胞和自然杀伤细胞的值没有差异。这些结果表明，先前报道的继发性血色素沉着症患者淋巴细胞亚群异常可能是由铁过载以外的因素引起的。
