Iwasaki T, Hamano T, Aizawa K, Kobayashi K, Kakishita E
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
Acta Haematol. 1997;98(2):104-8. doi: 10.1159/000203599.
We report 2 cases of plasma cell dyscrasia presenting with significantly elevated serum CA125 levels. The serum levels of CA125 from these patients correlated well with their serum M-protein levels. One patient had an IgG-kappa type extramedullary plasmacytoma with the culture supernatant from lymph node plasma cells showing a considerably high level of CA125 activity. The serum IgG fraction purified using a protein A column was devoid of any detectable CA125 activity, negating that the serum IgG M-protein from this patient might respond with a false-positive result in the CA125 immunoradiometric assay. The other patient had an IgG-lambda type plasma cell leukemia with the culture supernatant from peripheral mononuclear cells also showing a high level of CA125 activity. These observations may suggest that in plasma cell dyscrasias the CA125 antigen is spontaneously produced by tumor cells.
我们报告2例浆细胞异常增生症患者，其血清CA125水平显著升高。这些患者的血清CA125水平与其血清M蛋白水平密切相关。1例患者患有IgG-κ型髓外浆细胞瘤，淋巴结浆细胞的培养上清液显示出相当高的CA125活性。使用蛋白A柱纯化的血清IgG组分未检测到任何CA125活性，排除了该患者血清IgG M蛋白在CA125免疫放射分析中可能产生假阳性结果的可能性。另1例患者患有IgG-λ型浆细胞白血病，外周单个核细胞的培养上清液也显示出高水平的CA125活性。这些观察结果可能提示，在浆细胞异常增生症中，CA125抗原是由肿瘤细胞自发产生的。
