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CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

作者信息

Caux C, Massacrier C, Vanbervliet B, Dubois B, de Saint-Vis B, Dezutter-Dambuyant C, Jacquet C, Schmitt D, Banchereau J

机构信息

Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

出版信息

Adv Exp Med Biol. 1997;417:21-5. doi: 10.1007/978-1-4757-9966-8_4.

DOI:10.1007/978-1-4757-9966-8_4
PMID:9286332
Abstract
摘要

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CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.来自人脐带血的CD34+造血祖细胞在粒细胞-巨噬细胞集落刺激因子(GM-CSF)和肿瘤坏死因子α(TNFα)的作用下,沿着两条独立的树突状细胞途径分化。
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Progenitor recruitment and in vitro expansion of immunostimulatory dendritic cells from human CD34+ bone marrow cells by c-kit-ligand, GM-CSF, and TNF alpha.通过c-kit配体、粒细胞-巨噬细胞集落刺激因子(GM-CSF)和肿瘤坏死因子α(TNFα)从人CD34⁺骨髓细胞中招募祖细胞并进行免疫刺激性树突状细胞的体外扩增。
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Growth and differentiation of human dendritic cells from CD34+ progenitors.从CD34+祖细胞生成人树突状细胞并使其分化。
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TGF-beta 1 dependent generation of LAG+ dendritic cells from CD34+ progenitors in serum-free medium.在无血清培养基中,TGF-β1依赖CD34⁺祖细胞生成LAG⁺树突状细胞。
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Special susceptibility to apoptosis of CD1a+ dendritic cell precursors differentiating from cord blood CD34+ progenitors.从脐带血CD34 +祖细胞分化而来的CD1a +树突状细胞前体对细胞凋亡具有特殊易感性。
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