健康受试者中低密度脂蛋白产生脂过氧化物的能力：随年龄的变化

Low-density lipoprotein ability to generate lipoperoxides in healthy subjects: variations according to age.

作者信息

Tronel H, Antebi H, Felden F, Guerci B, Fremont S, Drouin P, Nicolas J P, Alcindor L G

机构信息

Laboratoire de Biochimie A, CHRU Nancy-Brabois, Vandoeuvre-lès-Nancy, France.

出版信息

Ann Nutr Metab. 1997;41(3):160-5. doi: 10.1159/000177991.

DOI:10.1159/000177991

PMID:9286465

Abstract

Oxidized low-density lipoproteins (LDLs) are recognized to be involved in atherosclerosis development. Since the plasma oxidized LDL assay is inadequate because of the short half-lives of LDLs, measurement of the in vitro ability of LDLs to generate lipoperoxides (LDL-GLs) has been preferred. The present study displays a profile of LDL-GLs in a group of 175 healthy subjects, using a method to measure thiobarbituric acid-reactive substances. We have observed an increased LDL-GL level according to age.

摘要

氧化型低密度脂蛋白（LDL）被认为与动脉粥样硬化的发展有关。由于LDL的半衰期较短，血浆氧化LDL检测方法并不完善，因此更倾向于测量LDL在体外产生脂过氧化物（LDL-GL）的能力。本研究采用一种测量硫代巴比妥酸反应性物质的方法，展示了175名健康受试者群体中LDL-GL的情况。我们观察到LDL-GL水平随年龄增长而升高。