Bernstein C N, Pettigrew N, Wang K K, Greenberg H, Lipschitz J
Department of Medicine, University of Manitoba, Winnipeg.
Can J Gastroenterol. 1997 Jul-Aug;11(5):403-6. doi: 10.1155/1997/967506.
Repeated laser therapy has become an accepted therapeutic approach in the treatment of watermelon stomach, and to date no important negative sequelae have been reported. The case of a patient who underwent repeated sessions of neodymium: yttrium aluminum garnet (Nd:YAG) laser therapy over a five-year period for the treatment of the watermelon stomach is presented. Postlaser therapy the patient developed deep ulcerations that would heal; however, he ultimately developed a nodular antrum. Random biopsies of antral nodules revealed carcinoma-in-situ. A Billroth I gastrectomy revealed two foci of carcinoma-in-situ/high grade dysplasia and multiple foci of lower grades of dysplasia. This case suggests a possible association between use of laser therapy and development of gastric neoplasia.
重复激光治疗已成为治疗西瓜胃的一种公认的治疗方法，迄今为止，尚未有重要的负面后遗症报道。本文介绍了一名患者的病例，该患者在五年期间接受了多次钕：钇铝石榴石（Nd:YAG）激光治疗以治疗西瓜胃。激光治疗后，患者出现了会愈合的深度溃疡；然而，他最终发展为结节性胃窦。胃窦结节的随机活检显示原位癌。毕罗Ⅰ式胃切除术显示有两个原位癌/高级别发育异常病灶和多个低级别发育异常病灶。该病例提示激光治疗的使用与胃肿瘤的发生之间可能存在关联。
