Yamada Y, Goto J, Yokota M
Department of Geriatric Research, National Chubu Hospital, Aichi, Japan.
Cardiology. 1997 Sep-Oct;88(5):401-7. doi: 10.1159/000177368.
We studied the relation between the plasma concentration of brain natriuretic peptide (BNP) and echocardiographic findings to determine the sensitivity of BNP as an indicator of left-ventricular dysfunction in elderly patients with various cardiovascular diseases. The plasma concentration of BNP was positively correlated with left-ventricular end-diastolic and end-systolic dimensions (LVEDD and LVESD, respectively) and inversely correlated with the left-ventricular ejection fraction (LVEF) in patients with prior myocardial infarction, dilated cardiomyopathy, and valvular heart disease. The plasma concentration of BNP decreased significantly in association with an increase in LVEF and decreases in LVEDD and LVESD in patients with congestive heart failure following therapy. These observations indicate that the plasma concentration of BNP is a sensitive marker of impaired left-ventricular function in elderly patients with various cardiovascular diseases and may be useful for evaluating the improvement in left-ventricular function and the efficacy of therapy in patients with congestive heart failure.
我们研究了脑钠肽（BNP）血浆浓度与超声心动图检查结果之间的关系，以确定BNP作为各种心血管疾病老年患者左心室功能障碍指标的敏感性。在既往有心肌梗死、扩张型心肌病和瓣膜性心脏病的患者中，BNP血浆浓度与左心室舒张末期和收缩末期内径（分别为LVEDD和LVESD）呈正相关，与左心室射血分数（LVEF）呈负相关。在充血性心力衰竭患者接受治疗后，随着LVEF升高以及LVEDD和LVESD降低，BNP血浆浓度显著下降。这些观察结果表明，BNP血浆浓度是各种心血管疾病老年患者左心室功能受损的敏感标志物，可能有助于评估充血性心力衰竭患者左心室功能的改善情况及治疗效果。
