准分子激光原位角膜磨镶术后局部应用皮质类固醇激素的效果。
Effects of topical corticosteroids after photorefractive keratectomy.
作者信息
Chatterjee A, Shah S, Galway G
机构信息
Optimax Laser Eye Clinic, London, England.
出版信息
J Refract Surg. 1997 Aug;13(5 Suppl):S454-5. doi: 10.3928/1081-597X-19970801-18.
PURPOSE
To assess the effects of topical corticosteroids (fluoromethalone) following photorefractive keratectomy (PRK).
METHODS
Both eyes of 654 patients had PRK with a minimum of 4 months between treatments. Topical corticosteroids were prescribed for one eye only. Endpoints were assessed by comparing the ratio of intended to actual refractive change in the corticosteroid treated eye with the fellow eye (no corticosteroid use).
RESULTS
The corticosteroid treated eyes showed a mean percentage correction of 95.7% compared to the untreated fellow eyes, which achieved a percentage correction of 103.3%-statistical significance of p = 0.00001. There was more of a trend toward regression in the corticosteroid treated eyes despite intervention with fluoromethalone.
CONCLUSION
Topical corticosteroids showed very little positive effect on regression of effect after PRK.
目的
评估准分子激光角膜切削术（PRK）后局部应用皮质类固醇（氟米龙）的效果。
方法
654例患者双眼均接受PRK治疗，两次治疗间隔至少4个月。仅对一只眼睛开具局部皮质类固醇药物。通过比较皮质类固醇治疗眼与对侧眼（未使用皮质类固醇）预期屈光变化与实际屈光变化的比率来评估终点指标。
结果
与未治疗的对侧眼相比，接受皮质类固醇治疗的眼睛平均矫正百分比为95.7%，而未治疗的对侧眼矫正百分比为103.3%，p = 0.00001，具有统计学意义。尽管使用了氟米龙进行干预，但接受皮质类固醇治疗的眼睛仍有更多的回退趋势。
结论
局部应用皮质类固醇对准分子激光角膜切削术后效果的回退几乎没有积极作用。
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