[准分子激光原位角膜磨镶术后皮质类固醇的应用]
[The application of corticosteroid following photorefractive keratectomy].
作者信息
Li W, Wang H, Jiang X
机构信息
Photorefractive Keratectomy Center, Hunan Provincial People's Hospital, Changsha.
出版信息
Zhonghua Yan Ke Za Zhi. 1997 Jan;33(1):16-8.
OBJECTIVE
The application methods of corticosteroid following excimer laser photorefractive keratectomy (PRK) were compared.
METHODS
PRK was performed on 600 myopic eyes with Nidek-EC 5000 PRK System, and then randomly they were divided into group A (228 eyes) and B (372 eyes). Different methods of application of corticosteroid were performed in the two groups. The follow-up period was 6 months.
RESULTS
After 6 months of follow-up, the rate of uncorrected visual acuity > or = 0.8 or > or = 1.0 was 97.9%, 93.2% in group A and 98.6%, 93.5% in group B, respectively. Transient ocular hypertension occurred in 2.2% in group A and 2.7% in group B, but the difference was statistically not significant (P > 0.05), the rate of haze greater than grade 1 was 18.4% in group A and 5.4% in group B, with statistically significant difference (P < 0.05).
CONCLUSION
After PRK, the appropriate application of corticosteriod can effectively reduce the rate of haze formation and regression towards myopia caused by haze. Powerful corticosteroid used at postoperative early stage and its low concentration at later stage can reduce the incidence of corticosteroid ocular hypertension.
目的
比较准分子激光屈光性角膜切削术（PRK）后糖皮质激素的应用方法。
方法
用Nidek-EC 5000 PRK系统对600只近视眼施行PRK，然后将其随机分为A组（228只眼）和B组（372只眼）。两组采用不同的糖皮质激素应用方法。随访期为6个月。
结果
随访6个月后，A组未矫正视力≥0.8或≥1.0的比例分别为97.9%、93.2%，B组分别为98.6%、93.5%。A组短暂性高眼压发生率为2.2%，B组为2.7%，但差异无统计学意义（P>0.05）；A组 haze大于1级的比例为18.4%，B组为5.4%，差异有统计学意义（P<0.05）。
结论
PRK术后，合理应用糖皮质激素可有效降低 haze形成率及 haze所致近视回退率。术后早期应用强效糖皮质激素，后期应用低浓度糖皮质激素可降低糖皮质激素性高眼压的发生率。
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