HIV-1进入的共受体。

Co-receptors for HIV-1 entry.

作者信息

Moore J P, Trkola A, Dragic T

机构信息

The Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10021, USA.

出版信息

Curr Opin Immunol. 1997 Aug;9(4):551-62. doi: 10.1016/s0952-7915(97)80110-0.

DOI:10.1016/s0952-7915(97)80110-0

PMID:9287172

Abstract

HIV-1 enters its target cells by fusion at the plasma membrane. The primary cellular receptor for HIV is CD4, but this molecule is insufficient to permit viral fusion. During 1996, the necessary entry co-factors (co-receptors or second receptors) were identified as being members of the seven-transmembrane-spanning receptor family fusin: CXCR4 for T-tropic strains and CCR5, principally, for M-tropic strains. The co-receptor functions of these proteins are inhibited by their natural alpha- and beta-chemokine ligands.

摘要

HIV-1通过在质膜处融合进入其靶细胞。HIV的主要细胞受体是CD4，但该分子不足以允许病毒融合。1996年期间，必要的进入辅助因子（共受体或第二受体）被确定为七跨膜受体家族融合素的成员：T嗜性毒株的CXCR4和主要为M嗜性毒株的CCR5。这些蛋白质的共受体功能受到其天然α和β趋化因子配体的抑制。