Isotalo E, Pyykkö I
Department of Otorhinolaryngology, University Hospital of Helsinki, Finland.
Acta Otolaryngol Suppl. 1997;529:123-6. doi: 10.3109/00016489709124101.
In this study data of voluntary eye movements 62 patients (mean age was 49.6 years) with Meniere's disease and 38 healthy control subjects were examined. Pseudo-random smooth pursuit (PRPEM) tests were conducted with frequency combination of 0.25 and 0.425 Hz. Saccades at constant targets and pseudo-randomly shifting targets were evaluated. In logistic regression analysis constant saccades correctly classified the cases in 57% as saccadic latency discriminating the groups best, latency being longer in Meniere group. In pseudo-random saccades, correct classification was achieved in 75.4% of all cases as latency discriminating the groups best, and latency was longer in Meniere group. In PRPEM, correct classification was achieved in 65.3% of all cases as gain by amplitude (GA), discriminating the groups best, and GA was smaller in Meniere group. Pseudo-random saccade test is a demanding task and that may explain why a peripheral vestibular lesion may interfere visual tracking and scanning performance. Latency is the most vulnerable of parameters to be lesioned. Results indicate that a peripheral vestibular lesion influences the control of voluntary eye movements and may explain the complaints of visual targeting on objects that patients with Meniere's disease have.
在本研究中，对62例梅尼埃病患者（平均年龄49.6岁）和38名健康对照者的随意眼球运动数据进行了检查。以0.25和0.425Hz的频率组合进行了伪随机平滑跟踪（PRPEM）测试。对固定目标和伪随机移动目标的扫视进行了评估。在逻辑回归分析中，固定扫视以扫视潜伏期对组进行最佳区分，梅尼埃病组的潜伏期更长，在57%的病例中正确分类。在伪随机扫视中，以潜伏期对组进行最佳区分，梅尼埃病组的潜伏期更长，在所有病例中有75.4%实现了正确分类。在PRPEM中，以幅度增益（GA）对组进行最佳区分，梅尼埃病组的GA较小，在所有病例中有65.3%实现了正确分类。伪随机扫视测试是一项要求较高的任务，这可能解释了为什么外周前庭病变可能会干扰视觉跟踪和扫视性能。潜伏期是最易受损伤的参数。结果表明，外周前庭病变会影响随意眼球运动的控制，并可能解释梅尼埃病患者对物体视觉定位的主诉。
