Isotalo E, Niemelä M, Pyykkö I, Summanen P
Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland.
Acta Otolaryngol Suppl. 1997;529:119-22. doi: 10.3109/00016489709124100.
We examined voluntary eye movements of 20 ophtalmologically screened patients (mean age of 51 years) with operated hemangioblastoma (HAB) in the cerebellum. Constant and pseudo-random saccades and pseudo-random smooth pursuit eye movement (PRPEM) test (with 4 frequency combinations) were evaluated. As controls 38 healthy subjects were examined. In the logistic regression analysis latency and accuracy of constant saccades were the best predictors for operated HAB with correct overall classification rate of 79.3%. Accuracy was worse and latency longer in operated HAB group than in control group. In pseudo-random saccades correct classification between the groups was achieved in 82.8% of all cases with latency and accuracy as predictors. In PRPEM test the best frequency combinations in differentiating operated HAB patients from controls were 0.25 and 0.425 Hz for gain, and 0.3 and 0.7 Hz for phase and gain, the correct overall classification rate being 73.3% in both cases. The characteristic changes in voluntary eye movements after removal of cerebellar hemangioblastoma seem to be insufficient timing of initiating the eye movement.
我们检查了20例经眼科筛查、患有小脑成血管细胞瘤（HAB）且已接受手术治疗的患者（平均年龄51岁）的随意眼动情况。对恒定性和伪随机扫视以及伪随机平稳跟踪眼动测试（有4种频率组合）进行了评估。作为对照，检查了38名健康受试者。在逻辑回归分析中，恒定性扫视的潜伏期和准确性是手术治疗的HAB的最佳预测指标，总体正确分类率为79.3%。手术治疗的HAB组的准确性低于对照组，潜伏期长于对照组。在伪随机扫视中，以潜伏期和准确性作为预测指标时，两组之间在所有病例中的正确分类率为82.8%。在伪随机平稳跟踪眼动测试中，区分手术治疗的HAB患者与对照组的最佳频率组合，增益方面为0.25和0.425Hz，相位和增益方面为0.3和0.7Hz，两种情况下的总体正确分类率均为73.3%。小脑成血管细胞瘤切除术后随意眼动的特征性变化似乎是眼动启动的时间不足。
