Rautiainen M, Virtanen T, Ruoppi P, Nuutinen J, Mäntyjärvi R
Department of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital, Finland.
Acta Otolaryngol Suppl. 1997;529:169-72. doi: 10.3109/00016489709124113.
During the indoor cattle feeding season, dairy farmers are continuously exposed to allergenic bovine-derived materials for a long time every year. Limited information is available about the dynamics of exposed people's antibody responses under the influence of this kind of exposure. In this study, the level of antibodies to bovine epithelial antigen (BEA) was found to reflect the level of clinical allergy. On the other hand, the level of immunoglobulin (Ig)E, IgA and IgG antibodies to bovine urinary antigen (BUA) was lower in the group of bovine-allergic farmers than among other farmers. It was concluded that antibodies to different allergen extracts reflect different phenomena. Antibodies to BEA seem to be associated more with allergic symptoms, where as anti-BUA antibodies might reflect the level of bovine exposure. The indoor cattle feeding season did not cause any major changes in dairy farmers' humoral responses. The continued allergen exposure did not increase the level of sensitization as determined by antibody responses.
在室内奶牛饲养季节，奶农每年都会长时间持续接触源自牛的过敏原物质。关于在这种接触影响下接触人群抗体反应动态的信息有限。在本研究中，发现牛上皮抗原（BEA）抗体水平可反映临床过敏水平。另一方面，对牛尿液抗原（BUA）的免疫球蛋白（Ig）E、IgA和IgG抗体水平在对牛过敏的奶农组中低于其他奶农。得出的结论是，针对不同过敏原提取物的抗体反映了不同的现象。BEA抗体似乎与过敏症状关联更大，而抗BUA抗体可能反映牛的接触水平。室内奶牛饲养季节并未导致奶农体液反应出现任何重大变化。持续的过敏原接触并未如抗体反应所确定的那样增加致敏水平。
