Lurie S, Fink A, Hagay Z J
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.
J Perinat Med. 1997;25(3):292-4. doi: 10.1515/jpme.1997.25.3.292.
This prospective study was undertaken to test the hypothesis that parathyroid hormone (PTH) might be involved in preterm or term labor. Four groups of patients were formed, 15 patients in each group. The preterm labor group were patients who were admitted to our perinatal care unit with preterm labor and unruptured membranes (< 35 weeks' gestation). The preterm or term nonlabor control groups were patients matched for gestational age, maternal age, and parity, who were not in labor. The term labor group were patients matched for maternal age and parity who were in active labor. Mean (+/-SD) level of biologically intact PTH was 18.9 +/- 10.6 pgr/mL, 7.6 +/- 4.7 pgr/mL, 20.8 +/- 10.1 pgr/mL, 13.7 +/- 5.3 pgr/mL in preterm labor group, preterm nonlabor group, term labor group, and term nonlabor group, respectively (p < 0.05). No statistically significant differences were observed in the levels of calcium, phosphorus, magnesium, or albumin. We therefore suggest that PTH may have a role in preterm or term labor. The nature of its role should be investigated in further studies.
本前瞻性研究旨在检验甲状旁腺激素（PTH）可能参与早产或足月分娩的假设。研究分为四组，每组15例患者。早产组为因早产且胎膜未破（妊娠<35周）入住我们围产期护理单元的患者。早产或足月未分娩对照组为在孕周、产妇年龄和胎次方面匹配的未分娩患者。足月分娩组为在产妇年龄和胎次方面匹配且处于活跃分娩期的患者。早产组、早产未分娩组、足月分娩组和足月未分娩组中生物活性完整的PTH平均（±标准差）水平分别为18.9±10.6皮克/毫升、7.6±4.7皮克/毫升、20.8±10.1皮克/毫升、13.7±5.3皮克/毫升（p<0.05）。在钙、磷、镁或白蛋白水平方面未观察到统计学显著差异。因此，我们认为PTH可能在早产或足月分娩中起作用。其作用的性质应在进一步研究中进行调查。
