Gremiakova T A, Fursova N K, Stepanov A V
State Scientific Center of Applied Microbiology, Obolensk.
Vestn Ross Akad Med Nauk. 1997(6):11-6.
The review deals with the world history and the current status of typhoid fever vaccination. It analyzes parenteral and oral killed cellular, oral live attenuated, molecular vaccines are analyzed. The results of field trials of parenteral and oral vaccines in the areas showing different epidemiology and incidence are analyzed. The problems in the designing of molecular typhi vaccines are considered. The results of designing the new generation vaccines S. typhi strains attenuated by means of site-specific mutagenesis and Vi-polysaccharide-protein conjugates are presented.
该综述涉及伤寒疫苗的世界历史和现状。分析了注射用和口服灭活细胞疫苗、口服减毒活疫苗、分子疫苗。分析了注射用和口服疫苗在不同流行病学和发病率地区的现场试验结果。考虑了分子伤寒疫苗设计中的问题。介绍了通过位点特异性诱变减毒的伤寒杆菌菌株和Vi-多糖-蛋白偶联物等新一代疫苗的设计结果。
